WebAug 17, 2024 · We detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome P450–amidotransferase enzyme pair and highlights the first oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group from a … http://ctdbase.org/detail.go?type=chem&acc=C000630558
Enzymatic C-H Oxidation-Amidation Cascade in the Production of …
WebAn unprecedented two-step biosynthetic conversion of the natural product thiotetromycin to thiotetroamide C involving the tandem oxidation and amidation of an unreactive alkyl group has been reported. 28 This is the first report of an oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group ... WebSep 25, 2024 · The selective activation of unreactive hydrocarbons by biosynthetic enzymes has inspired new synthetic methods in C-H bond activation. Herein, we report the … rolly rolly rolly rolly dab ranch
Targeting Bacterial Genomes for Natural Product Discovery
WebWe detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome P450–amidotransferase enzyme pair and highlights the first oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group from a chemically inert alkyl … WebSep 1, 2024 · Four new triterpenoid saponins, clematochinenoside H–K (1–4), and five known structures (5–9), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on... WebHerein, we report the unprecedented two-step biosynthetic conversion of thiotetromycin to thiotetroamide C involving the tandem carboxylation and amidation of an unreactive ethyl group. We detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome P450 ... rolly rolly rolly with a dab of ranch lyrics