WebApr 20, 2024 · CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). CBL0137 is a potent inducer of apoptosis in pancreatic cancer cell lines and is … WebSamples have been processed into three unique libraries: a lead-like extract library, a lead-like fraction library, and a pure compound library, which are ready for screening to discover new bioactive compounds in a range of applications (e.g., biomedical, agrochemical, nutraceutical). Also holds more than 30,000 archived biota samples.
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WebNCI Data Catalog. The NCI Data Catalog is a listing of data collections produced by major NCI initiatives and other widely used data sets. Data collections included in the catalog meet the following criteria: Produced by NCI intramural researchers or major NCI initiatives, or regularly referenced NCI-funded extramural research data. WebApr 11, 2024 · Here, we describe NS clinical and genetic features of homogenous patient group: 9 individuals from 7 families with similar ethnic background and who have the same SPINK5 variant (NM_006846.4: c.1048C > T, p.(Arg350*)) in homozygous or compound heterozygous states, suggesting that it is a common founder variant in Latvian … randall ford artist
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WebApr 7, 2024 · Information from the National Library of Medicine. ... Normal renal function as determined by Investigator following review of clinical laboratory test results, including eGFR as estimated using the CKD EPI equation. ... (EXCEPT biological compound) within 30 days or receipt of biological compound within 90 days (or 5 half lives, whichever is ... WebDescription. Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. Targets. WebPemrametostat (GSK3326595) Catalog No.S8664 Synonyms: EPZ015938. For research use only. Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models. CAS No. 1616392-22-3. over the calf socks nike